FRUCTOSE INDUCED HYPERURICEMIA PDF

Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans. Virgile Lecoultre, PHD1,; Léonie Egli, MSC1,; Fanny. Fructose-induced hyperuricemia and hyperuricaciduria is associated with a striking increase in the blood lactate concentration, a decrease in erythrocyte. As such, we propose that the epidemic of the metabolic syndrome is due in part to fructose-induced hyperuricemia that reduces endothelial NO levels and.

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Consistent with this hypothesis is the observation that changes in mean uric acid levels correlate with the increasing frutose of metabolic syndrome in the US and developing countries.

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Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans

Parts of this study were presented in abstract form at Experimental BiologyBoston, Massachusetts, 20—24 April Closed symbols represent data collected after 4—6 days of HFrD.

In two patients with hereditary fructose intolerance HFI the peak blood uric acid levels were Published online Aug The mean blood inorganic phosphate Pi levels were significantly less than the mean fasting value after fructose. Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: Support Center Support Center.

These samples were collected while subjects were participating in two clinical trials clinical trial reg. Journal List Diabetes Care v.

Nutr Metab Lond ; 9: These observations suggest that a decreased urinary UA excretion may contribute to fructose-induced hyperuricemia. We recently reported that uric acid reduces levels of endothelial nitric oxide NOa key mediator of insulin action.

This study was supported by grant from the Swiss National Foundation for Science and by a grant from Ajinomoto Co. In addition, we observed that a serum uric acid level above 5.

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The lack of hyperruricemia in galactosemia patients after galactose ingestion may be explained by the observation that galactose is phosphorylated more slowly than fructose.

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The mean uric acid excretion, expressed as milligrams per mg urinary creatinine, was 0. Although the cumulative fructose load was large 1. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. Acknowledgments This study was supported by grant from the Swiss National Foundation for Science and by a grant from Ajinomoto Co. As such, we propose that the epidemic of the metabolic syndrome is due in part to fructose-induced hyperuricemia that reduces endothelial NO levels and induces insulin resistance.

The serum Pi levels decreased less in galactosemic patients after galactose administration than in patients with HFI after fructose infusion. Furthermore, high-fructose intake over several days is associated with increased fasting UA concentration 1.

F—F [ PubMed ]. National Center for Biotechnology InformationU.

Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans

The increasing incidence of obesity and the metabolic syndrome over the past two decades has coincided with a marked increase in total fructose intake. Exercise prevents fructose-induced hypertriglyceridemia in healthy young subjects.

Urinary UA excretion rate. The serum Pi level decreased 2. This article has been cited by other articles in PMC. These effects are generally attributed to an increased UA production, hypeturicemia observed after intravenous fructose administration 2.

Am J Physiol Renal Physiol ; Because the metabolic effects of fructose show significant sex differences, it remains to be assessed whether the same effects are observed in female subjects. Studies in humans should be performed to address whether lowering uric acid levels will help to prevent this condition.

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In two patients with HFI the uric acid excretion hyperuricekia four- to fivefold after fructose administration; the increased uric acid excretion in HFI exceeded that of normal children.

This mechanism may substantially enhance the risk of gout in people who consume high amounts of sugar. Blood glucose, lactic acid, and fructose levels were significantly increased indhced fructose, but serum magnesium levels did not change.

It has not been assessed, however, whether UA also increases when fructose is administered as several small drinks instead of one single large load or whether a high-fructose diet HFrD impairs renal UA clearance UAC or fractional excretion UAFE as observed in rats 3.

Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans. Fructose-induced hyperuricemia results in endothelial dysfunction and insulin resistance, and might be a novel causal mechanism of the metabolic syndrome.

NO increases blood flow to skeletal muscle and enhances glucose uptake.

Animals deficient in endothelial NO develop insulin resistance and other features induces the metabolic syndrome.

This effect appears to be specific for fructose. After the infusion of fructose, 0. Open in a separate window. Am J Clin Nutr ; These studies support the hypothesis that fructose-induced hyperuricemia results from degradation of adenosine monophosphate.